Updated NETs Clinical Trials

1. Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance

   Conditions: Vitamin b12; Supplementation During Endurance Performance; Flavonoids; Mental Fatigue; Biomarker Feedback Interventions: Dietary Supplement: Vitamin B 12; Dietary Supplement: Natural orange extract; Combination Product: Vitamina B12 + natural orange extract; Dietary Supplement: Microcrystalline Cellulose Sponsors: Francisco Javier Martínez Noguera Enrolling by invitation

2. Abdominal Circumference as a Predictor of Operative Time in Retroperitoneal Adrenalectomy for Pheochromocytoma

   Conditions: Pheochromocytoma Malignant Interventions: Procedure: Retroperitoneal Adrenalectomy Sponsors: Asan Medical Center Completed

3. The Effects of Transcranial Current Stimulation on Insomnia

   Conditions: Insomnia, Psychophysiological Interventions: Device: transcranial current stimulation; Device: Sham stimulation Sponsors: Zan Wang Active, not recruiting

4. Trial of FOLFIRI + Zimberelimab + Domvanalimab vs FOLFIRI With a Hybrid Synthetic Control Arm in Second Line Treatment of Neuroendocrine Carcinoma of Gastro-enteropancreatic or Unknown Origin (REWENEC 01)

   Conditions: Carcinoma, Neuroendocrine Interventions: Drug: FOLFIRI + Zimberelimab + Domvanalimab; Drug: FOLFIRI (standard of care) Sponsors: Hospices Civils de Lyon; Federation Francophone de Cancerologie Digestive Not yet recruiting

5. Dostarlimab, Cisplatin and Etoposide in Combination With Radiotherapy in Sandwich Sequence for Small Cell Neuroendocrine Cervical Carcinoma

   Conditions: Female Interventions: Drug: Dostarlimab Sponsors: Chang Gung Memorial Hospital Recruiting

6. Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy

   Conditions: Pancreatic Ductal Adenocarcinoma; Ampullary Carcinoma; Distal Cholangiocarcinoma; Duodenal Adenocarcinoma; Pancreatic Neuroendocrine Tumor Interventions: Procedure: Open Pancreaticoduodenectomy; Procedure: Laparoscopic Pancreaticoduodenectomy Sponsors: Minia University Not yet recruiting

7. Metabolic and Muscle Profile in ICU Survivors

   Conditions: Critical Illness; Major Abdominal Surgeries Interventions: Diagnostic Test: Inflammation markers; Diagnostic Test: Blood nucleosomes; Diagnostic Test: Erythrocyte membrane fatty acid content; Diagnostic Test: measurement of myokines; Diagnostic Test: Resting energy expendure; Diagnostic Test: body composition; Diagnostic Test: Omics; Diagnostic Test: Monocyte profile Sponsors: Anne-Françoise Rousseau Recruiting

8. Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

   Conditions: Extensive-Stage Small Cell Lung Cancer; Extrapulmonary Neuroendocrine Carcinoma; Small Cell Carcinoma Interventions: Drug: Tarlatamab; Drug: Sacituzumab Govitecan Sponsors: National Cancer Institute (NCI) Not yet recruiting

9. Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

   Conditions: Ultrasound; External Oblique; Rectus Abdominis Plane Block; Neuroendocrine Stress Response; Umbilical Hernia Interventions: Other: General anesthesia; Other: External oblique and rectus abdominis plane (EXORA) block Sponsors: Tanta University Recruiting

10. Impact of Emotional Disorders on Response to Immune Checkpoint Inhibitor Therapy in Liver Cancer

    Conditions: Liver Cancer; Emotional Disorder Interventions: Other: Scale score Sponsors: Tongji Hospital Recruiting

11. DCEUS to Assess Treatment Response to PRRT in GEP-NET

    Conditions: NET; Radionucleide Therapy; Contrast Enhanced Ultrasound Interventions: Device: Vuebox Sponsors: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Recruiting

12. Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas

    Conditions: Cardiovascular Abnormalities; Arterial Blood Pressure; Heart Rate; Congestive Heart Failure Chronic; Coronary Syndrome; Cerebrovascular Disease; Myocarditis, Pericarditis; Hyperlipidaemia; Diabete Mellitus Sponsors: Laikο General Hospital, Athens Enrolling by invitation

13. A Two-decade Mortality Risk Analysis of Gastrointestinal Carcinoid Neoplasms: an Updated SEER-based Study 2000-2022

    Conditions: Carcinoid Tumor Sponsors: Suez Canal University Completed

14. Recent Trends in Stage Migration of Gastrointestnial Carcinoid Tumors Over Two Decades: a Retrospective SEER-based Analysis 2000-2022

    Conditions: Carcinoid Tumor; SEER Database Analysis; Stage Sponsors: Suez Canal University Completed

15. Study of Cabozantinib in Participants With Neuroendocrine Tumors Who Have Already Received Prior Treatment

    Conditions: Neuroendocrine Tumors Sponsors: Ipsen Not yet recruiting

16. Roy Adaptation Model Improves Mood and QOL After Giant Acoustic Neuroma

    Conditions: Acoustic Neuroma; Facial Paralysis Interventions: Behavioral: RAM-Based Nursing + RAM Follow-Up Care Sponsors: West China Hospital Completed

17. Nutritional Status Assessment in Adult Patients Followed for Gastroenteropancreatic Neuroendocrine Tumors at Strasbourg University Hospital

    Conditions: Gastroenteropancreatic Neuroendocrine Tumor Sponsors: University Hospital, Strasbourg, France Recruiting

18. Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

    Conditions: Large Cell Neuroendocrine Carcinoma; Large Cell Pulmonary Neuroendocrine Carcinoma of the Lung (LCNEC); Extrapulmonary Neuroendocrine Carcinoma (EP-NEC); Small Cell Lung Cancer (SCLC); Gastroenteropancreatic NEC (GEP NEC); NEC of the Bladder; Other DLL3 Expressing epNEC Interventions: Drug: [212Pb]Pb-MP0712; Other: [203Pb]Pb-MP0712 Sponsors: Molecular Partners AG; Orano Med LLC Recruiting

19. Pancreatic Neuroendocrine Tumour - Optimal Surgical Debulking or Not

    Conditions: Pancreatic Neuroendocrine Tumor Interventions: Procedure: Debulking surgery Sponsors: Uppsala University; Uppsala Clinical Research Center, Sweden Recruiting

20. Stress and Anxiety Effects on Valuation

    Conditions: Reward Value Level Interventions: Behavioral: Socially Evaluated Cold Pressor Task (SECPT); Behavioral: Non-Stressful Control Task Sponsors: NYU Langone Health Recruiting

21. Impact of Funcional Exercise and Supplementation in Perimenopausal Women's Health

    Conditions: Perimenopause; Aging Interventions: Dietary Supplement: Exercise + nutritional supplement; Dietary Supplement: Exercise + placebo supplement Sponsors: University of Valencia Recruiting

22. Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

    Conditions: Reproductive Disorder; Neurodegeneration; SARS-CoV 2 Interventions: Drug: Kisspeptin 112-121 Sponsors: Stephanie B. Seminara, MD; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting

23. RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma

    Conditions: Recurrent Meningioma Interventions: Drug: Actinium Ac 225 DOTATATE RYZ101; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Echocardiography Test; Radiation: Gallium Ga 68-DOTATATE; Drug: L-lysine/L-arginine-containing Amino Acid; Procedure: Magnetic Resonance Imaging; Procedure: Multigated Acquisition Scan; Procedure: Positron Emission Tomography; Procedure: Somatostatin Receptor Positron Emission Tomography Sponsors: Joshua Palmer; RayzeBio, Inc. Recruiting

24. A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

    Conditions: SST2-positive Neuroendocrine Neoplasms; Neuroendocrine Tumors; Neuroendocrine Neoplasm Interventions: Drug: CRN09682 Sponsors: Crinetics Pharmaceuticals Inc. Recruiting

25. 18F-AlF-NOTA-Octreotide PET in Neuroendocrine Neoplasms

    Conditions: Neuroendocrine Tumors Interventions: Diagnostic Test: 18F-AlF-NOTA-Octreotide PET-CT or PET-MR Sponsors: First Affiliated Hospital of Zhejiang University Not yet recruiting

26. Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version

    Conditions: Transgenderism; Reproductive Issues Interventions: Drug: Testosterone Cypionate 50 milligrams per millileter (mg/mL) Injectable Solution Sponsors: University of California, San Diego; National Institutes of Health (NIH); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Recruiting

27. Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors

    Conditions: Small-cell Lung Cancer; Neuroendocrine Cancer; Prostate Cancer; Gastrointestinal Neuroendocrine Tumor; Merkel Cell Carcinoma, Recurrent Interventions: Drug: BL-M14D1 Sponsors: SystImmune Inc. Recruiting

28. ZG006 and ZG005 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma

    Conditions: Small Cell Lung Cancer; Neuroendocrine Carcinoma Interventions: Drug: ZG006; Drug: ZG005 Sponsors: Suzhou Zelgen Biopharmaceuticals Co.,Ltd Recruiting

29. Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

    Conditions: Small Cell Lung Carcinoma; Large Cell Neuroendocrine Carcinoma of the Lung; Neuroendocrine Prostate Cancer; Gastroenteropancreatic Neuroendocrine Carcinoma Interventions: Drug: 225Ac-ETN029; Drug: 111In-ETN029 Sponsors: Novartis Pharmaceuticals Recruiting

30. Study of ZGGS18 in Combination With ZG005 in Patients With Advanced Solid Tumors

    Conditions: Advanced Solid Tumor Interventions: Biological: ZGGS18 for Injection; Biological: ZG005 for Injection Sponsors: Suzhou Zelgen Biopharmaceuticals Co.,Ltd Recruiting

31. Vasopressin in the Elderly: Physiological Changes in Neuroendocrine Function and Urinary Secretion in Healthy Aging

    Conditions: Healthy Ageing Interventions: Other: Hypertonic 3% saline; Other: Water Sponsors: University Hospital, Basel, Switzerland Completed

32. A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

    Conditions: Tumor Hyperinsulinism (Tumor HI) Interventions: Drug: Ersodetug Sponsors: Rezolute Recruiting

33. Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

    Conditions: Malignant Brain Neoplasm; Malignant Solid Neoplasm; Multiple Sclerosis; Neuroendocrine Tumor; Prostate Carcinoma Interventions: Procedure: Biospecimen Collection; Other: Exercise Intervention; Procedure: Magnetic Resonance Imaging; Other: Questionnaire Administration; Procedure: Respiratory Therapy Sponsors: Mayo Clinic Recruiting

34. Effects of TAP and QLB-1 Blocks on Opioid Consumption

    Conditions: Postoperative Pain Interventions: Procedure: Transversus Abdominis Plan Block (TAPB), Lateral Quadratum Lumborum (QLB-1) Block Sponsors: Başakşehir Çam & Sakura City Hospital Recruiting

35. Study to Test the Combination of Fulvestrant With Lu-DOTATATE for Advanced Pancreatic Neuroendocrine Tumors

    Conditions: Metastatic Pancreatic Neuroendocrine Tumor Interventions: Drug: Fulvestrant; Drug: 177Lu-DOTATATE Sponsors: University of Chicago Recruiting

36. Institutional Registry of Rare Diseases

    Conditions: Rare Diseases; Amyloidosis; Sarcoidosis; Phacomatosis; Pheochromocytoma; Paraganglioma; Von Hippel-Lindau Disease; Immunoglobulin G4-Related Disease; Demyelinating Diseases; Inborn Errors of Metabolism; Eosinophilic Gastrointestinal Disorders; Hypertrophic Cardiomyopathy; Gaucher Disease; Congenital Adrenal Hyperplasia; Hereditary Angioedema; Pulmonary Hypertension; Wilson Disease; Vascular Anomalies; Mastocytosis; Multiple Endocrine Neoplasia; Inflammatory Bowel Diseases; Prader-Willi Syndrome; Hirschsprung Disease; Cushing Syndrome; HHT; Hemorrhagic Hereditary Telangiectasia Sponsors: Hospital Italiano de Buenos Aires Recruiting

37. Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy

    Conditions: Prostate Cancer; Bladder Cancer; Surgery; Renal Impairment; Renal Injury, Acute Interventions: Procedure: Nitroglycerin Infusion; Procedure: Mannitol Infusion; Procedure: Fluid Regimen Sponsors: Nazmy Edward Seif Active, not recruiting

38. ATRX/DAXX in EUS-FNB Specimens of Pan-NETs

    Conditions: Pancreatic Neuroendocrine Tumor Interventions: Diagnostic Test: ATRX/DAXX immunohistochemistry Sponsors: Azienda Ospedaliera Universitaria Integrata Verona Active, not recruiting

39. A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity

    Conditions: Carcinoma, Neuroendocrine; Tumor, Neuroendocrine; Tumors, Neuroendocrine; Neuroendocrine; Carcinoma; Small Cell; Receptors Interventions: Drug: Belinostat; Drug: Cisplatin; Drug: Etoposide Sponsors: National Cancer Institute (NCI) Recruiting

40. A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

    Conditions: Basal Ganglia Germinoma; Central Nervous System Germinoma; Diabetes Insipidus; Pineal Region Germinoma; Suprasellar Germinoma; Thalamic Germinoma Interventions: Radiation: 3-Dimensional Conformal Radiation Therapy; Procedure: Biospecimen Collection; Drug: Carboplatin; Drug: Etoposide; Radiation: Intensity-Modulated Radiation Therapy; Procedure: Lumbar Puncture; Procedure: Magnetic Resonance Imaging; Other: Questionnaire Administration; Procedure: Surgical Procedure Sponsors: Children's Oncology Group Recruiting

41. Influence of Tumour and Patient's Related Factors on the Response to Medical Treatments in Well Differentiated GEP-NENs

    Conditions: Neuroendocrine Tumors; GEP-NET Sponsors: IRCCS San Raffaele Recruiting

42. Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

    Conditions: Central Nervous System (CNS) Lesions; Brain Metastases; Brain Neoplasms; Brain Neoplasms, Benign; Brain Tumor, Primary; Brain Tumor, Recurrent; Brain Tumors; Brain Cancer; Brain Tumor; Brain Neoplasm, Primary; Multiple Sclerosis; Multiple Sclerosis Brain Lesion; Neurofibroma; Acoustic Neuroma; CNS Tumor; CNS Lesion; CNS Metastases; CNS Cancer; CNS Lymphoma; Von Hippel Lindau; Meningioma; Glioma; Schwannomas; Neuroinflammation; Neoplasia Interventions: Drug: RVP-001 Sponsors: Reveal Pharmaceuticals Inc.; National Cancer Institute (NCI) Completed

43. Risk Factors for Neuroendocrine Neoplasms

    Conditions: Neuroendocrine Neoplasm of Lung; Neuroendocrine Neoplasm of Gastrointestinal Tract (Disorder) Interventions: Other: Case-control study (no intervention) Sponsors: Bavarian Cancer Registry; Bavarian Association of Statutory Health Insurance Accredited Physicians Recruiting

44. A Study of Etoposide-carboplatin in Combination With Pembrolizumab and Lenvatinib Maintenance in HG-NETs

    Conditions: Neuroendocrine Tumors Interventions: Combination Product: Pembrolizumab in combination with carboplatin and etoposide chemotherapy followed by pembrolizumab and lenvatinib maintenance therapy Sponsors: Imperial College London Active, not recruiting

45. Role of ChatGPT in Vestibular Schwannoma Management

    Conditions: Vestibular Schwannoma Interventions: Behavioral: Use of chatGPT for 1 week Sponsors: University of Southern California Withdrawn

46. A Clinical Trial of LBL-024 Combined With Etoposide and Platinum in Patients With Advanced Neuroendocrine Carcinoma

    Conditions: Advanced Neuroendocrine Carcinoma Interventions: Drug: LBL-024 for Injection; Drug: Etoposide Injection; Drug: Carboplatin Injection; Drug: Atezolizumab injection; Drug: Cisplatin injection Sponsors: Nanjing Leads Biolabs Co.,Ltd Recruiting

47. Using Novel Imaging to More Safely Treat Neuroendocrine Tumors

    Conditions: Neuroendocrine Tumors; Somatostatin Receptor-positive Neuroendocrine Tumor Interventions: Device: Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT); Device: Photon Emission Tomography / CT (PET/CT); Drug: 64Cu-Dotatate; Drug: 177Lu-Dotatate Sponsors: University of Wisconsin, Madison Recruiting

48. Triple Immune Checkpoint Inhibition for Advanced or Metastatic PD-(L)1 Refractory Merkel Cell Carcinoma

    Conditions: Unresectable Clinical Stage III Merkel Cell Carcinoma AJCC v8; Clinical Stage IV Merkel Cell Carcinoma AJCC v8; Merkel Cell Carcinoma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Biological: Retifanlimab; Drug: Tuparstobart; Drug: Verzistobart Sponsors: University of Washington; Incyte Corporation Active, not recruiting

49. Comparison of Adjuvant Treatment With 177Lu-DOTATATE to Best Supportive Care in Patients After Resection of Neuroendocrine Liver Metastases

    Conditions: Neuroendocrine Tumor G1 (NET G1)/Carcinoid; Neuroendocrine Tumor Grade 2; Neuroendocrine Tumors; Liver Metastases; Gastroenteropancreatic Neuroendocrine Tumor; Gastroenteropancreatic Neuroendocrine Neoplasm Interventions: Drug: Lutathera Sponsors: Imperial College London; The Taylor Family 2010 Charitable Trust; Novartis/AAA Terminated

50. Study of ZG006 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma

    Conditions: Small Cell Lung Cancer; Neuroendocrine Carcinoma Interventions: Biological: ZG006 Sponsors: Suzhou Zelgen Biopharmaceuticals Co.,Ltd Recruiting