Updated NETs Clinical Trials

• Survival Without Persistent Limiting Toxicity: Real Life Prospective Cohort of Advanced Neuroendocrine Tumor

  Conditions: Neuroendocrine (NE) Tumors Interventions: Other: quality of life questionnaire, treatment side effect follow up Sponsors: Gustave Roussy, Cancer Campus, Grand Paris Not yet recruiting

• Neuroendocrine Response in Pediatric Febrile Seizures

  Conditions: Febrile Convulsion; Neuroendocrine Stress Response; Fever Sponsors: Aydin Adnan Menderes University Not yet recruiting

• Chinese Classics Recitation Training in Subjective Cognitive Decline

  Conditions: Subjective Cognitive Decline (SCD); Subjective Cognitive Decline Interventions: Behavioral: Memory training by Chinese Classics recitation Sponsors: China Medical University Hospital Not yet recruiting

• Management of Pancreatic Cystic Lesions Using Artificial Intelligence Based on EUS and Multimodal Data

  Conditions: Pancreatic Cystic Lesion; Mucinous Cystadenoma of Pancreas; Intraductal Papillary Mucinous Neoplasm of Pancreas; Pseudocyst Pancreas; Serous Cystadenoma; Neuroendocrine Tumors, NET Interventions: Diagnostic Test: Cyst-AI model Sponsors: Huazhong University of Science and Technology Recruiting

• Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors.

  Conditions: Cushing Disease; ACTH-producing Pituitary Tumour Interventions: Other: Data-only evaluation of [18F]FET PET, pituitary MRI, and biomarkers Sponsors: Hospices Civils de Lyon Recruiting

• DLL3-Targeted PET/CT in Neuroendocrine Carcinoma

  Conditions: DLL3-expressing Tumors; PET / CT; Neuroendocrine Cancer Interventions: Diagnostic Test: Diagnostic Test: conventional imaging (CT, MRI or 18F-FDG PET/CT), DLL3-targeted PET/CT Sponsors: The First Affiliated Hospital of Xiamen University Recruiting

• Stress Reduction Program for Iraqi Medical Students

  Conditions: Psychological Stress; Academic Stress Interventions: Behavioral: Mindfulness-Based Stress Reduction Program Sponsors: University of Thi-Qar Completed

• CardioNETPOL National Registry of Carcinoid Heart Disease

  Conditions: Carcinoid Heart Disease; Neuroendocrine Tumors; Carcinoid Syndrome; Valvular Heart Disease Patients Interventions: Other: Observational Registry of Carcinoid Heart Disease Sponsors: National Institute of Cardiology, Warsaw, Poland Not yet recruiting

• The Effect of BWSTT on Neuroendocrine Profile and Functional Recovery in Stroke Patients

  Conditions: Stroke, Ischemic; Subacute Stroke Interventions: Device: Body Weight Support Treadmill Training (BWSTT); Behavioral: Overground Training Sponsors: Jagiellonian University Completed

• AI-Powered Precision Decision-Making for Pancreatic Diseases

  Conditions: Pancreatic Cancer; Diagnose Disease; IPMN, Pancreatic; Pancreatic Cystic Lesions; Chronic Pancreatitis; Pancreatic Neuroendocrine Tumor; Acute Pancreatitis (AP) Interventions: Diagnostic Test: Diagnosis by Artificial Intelligence model Sponsors: Changhai Hospital; The First Affiliated Hospital with Nanjing Medical University; The Affiliated People's Hospital of Ningbo University; The Second Affiliated Hospital of Jiaxing University; Shanghai Changzheng Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine; Shengjing Hospital; Shanghai Fourth People's Hospital Tongji University; The First Affiliated Hospital of Medical School of Zhejiang University; Shanghai Fudan University Cancer Center Recruiting

• Impact of Emotional Status on Prognosis of Patients With BCLC Stage B/C Hepatocellular Carcinoma Undergoing Hepatic Arterial Infusion Chemotherapy Combined With Targeted and Immunotherapy

  Conditions: Hepatocellular Carcinoma (HCC); Emotional Distress; HAIC(Hepatic Artery Infusion Chemotherapy); Immunotherapy; Targeted Therapy Sponsors: Nanfang Hospital, Southern Medical University Recruiting

• Efficacy and Safety of Shatavari Root Extract in Women's Sexual Wellness

  Conditions: Sexual Wellness; Women Health Interventions: Dietary Supplement: Shatavari (Asparagus racemosus) Root Extract; Other: Placebo Capsule Sponsors: SF Research Institute, Inc.; Ixoreal Biomed Private Limited Not yet recruiting

• CompArative Analysis Between, Thymic, pulmonaRy and Pancreatic Well Differentiated High Grade Neuroendocrine Tumors

  Conditions: Neuroendocrine Carcinoma of Lung; Neuroendocrine Carcinoma of Thymus Sponsors: European Institute of Oncology Recruiting

• Assessment of Patient Experience With Auto-Captioning Glasses in NF2-Related-Schwannomatosis

  Conditions: NF2-related Schwannomatosis Interventions: Device: Auto-captioning Glasses Sponsors: Massachusetts General Hospital Recruiting

• A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HLX3901 in Patients With Advanced SCLC or NEC

  Conditions: SCLC; NEC Interventions: Drug: HLX3901 Sponsors: Shanghai Henlius Biotech Not yet recruiting

• Endoscopic Management of Biliopancreatic Disease in the Lombardy Pancreas Units

  Conditions: Pancreatic Cancer; Biliopancreatic Diseases; Periampullary Neoplasms Sponsors: IRCCS San Raffaele Not yet recruiting

• Development and Clinical Application of a Novel Imaging Grading System for Pheochromocytoma and Paraganglioma (PPGL)

  Conditions: Risk Grading System; Pheochromocytoma and Paraganglioma (PPGL); Quantitative Assessment Interventions: Other: observational diagnostic model development Sponsors: Peking University First Hospital Completed

• A Clinical Study for the Efficacy and Safety of BL0020 Injection in Patients With Small Cell Lung Cancer Transformed From Non-Small Cell Lung Cancer Following EGFR TKI Therapy

  Conditions: Small Cell Carcinoma of Lung Interventions: Drug: BL0020 Sponsors: Shanghai Best-Link Bioscience, LLC Not yet recruiting

• Hypiend - Multicomponent Behavioral Intervention in Pre-puberal Children (Hypiend-PPC)

  Conditions: Precocious Puberty, Central; Executive Dysfunction Interventions: Behavioral: Multi-Component Behavioral intervention; Behavioral: Information Sponsors: Sciensano; Fundació Institut Germans Trias i Pujol; University of Liege; European Union (Horizon Europe Programme); Fundació Eurecat Active, not recruiting

• Advanced Endoscopic Resections for Rectal Neoplasms

  Conditions: Rectal Cancer; Rectal Adenocarcinoma; Rectal Adenoma; Rectal Neuroendocrine Neoplasm; Recurrent Rectal Adenocarcinoma Interventions: Procedure: Endoscopic submucosal dissection; Procedure: Endoscopic intramuscular dissection Sponsors: Jagiellonian University Not yet recruiting

• TheraSphere Japan Pre-Market Study

  Conditions: Liver Neoplasms Interventions: Device: TheraSphere Y-90 glass microsphere Sponsors: Boston Scientific Corporation Recruiting

• Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

  Conditions: Extensive-Stage Small Cell Lung Cancer; Extrapulmonary Neuroendocrine Carcinoma; Small Cell Carcinoma Interventions: Drug: Tarlatamab; Drug: Sacituzumab Govitecan Sponsors: National Cancer Institute (NCI) Not yet recruiting

• Study of Cabozantinib in Participants With Neuroendocrine Tumors Who Have Already Received Prior Treatment

  Conditions: Neuroendocrine Tumors Sponsors: Ipsen Recruiting

• TIL Therapy in cSCC and MCC

  Conditions: Cutaneous Squamous Cell Carcinoma; Merkel Cell Carcinoma; Metastatic Cutaneous Squamous Cell Carcinoma; Skin Cancer Interventions: Biological: LN-145; Drug: Cyclophosphamide; Drug: Fludarabine; Biological: Interleukin-2 Sponsors: Karam Khaddour, MD, MS; Iovance Biotherapeutics, Inc. Recruiting

• Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and Paraganglioma

  Conditions: Advanced Pheochromocytoma and Paraganglioma; PCPG Interventions: Drug: ONC206; Drug: ONC206: Dose 1; Drug: ONC206: Dose 2 Sponsors: Jazz Pharmaceuticals Recruiting

• Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

  Conditions: Reproductive Disorder; Neurodegeneration; SARS-CoV 2 Interventions: Drug: Kisspeptin 112-121 Sponsors: Stephanie B. Seminara, MD; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Recruiting

• Combination External Radiation and PRRT for Large GI Neuroendocrine Tumors.

  Conditions: Digestive System Neuroendocrine Tumor; Unresectable Digestive System Neuroendocrine Neoplasm; Unresectable Digestive System Neuroendocrine Tumor G1; Unresectable Digestive System Neuroendocrine Tumor G2 Interventions: Radiation: Stereotactic Body Radiation Therapy; Drug: Lutetium Lu 177 Dotatate; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Radiation: Gallium Ga 68-DOTATATE; Procedure: Positron Emission Tomography; Other: Questionnaire Administration Sponsors: Emory University; National Cancer Institute (NCI) Recruiting

• A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

  Conditions: SST2-positive Neuroendocrine Neoplasms; Neuroendocrine Tumors; Neuroendocrine Neoplasm Interventions: Drug: CRN09682 Sponsors: Crinetics Pharmaceuticals Inc. Recruiting

• DeniLA: Comprehensive Demographics and Clinical Profile of NSCLC Patients: Analyzing Guideline-Concordant Care in First-line Treatment Patterns

  Conditions: Lung Neoplasms Sponsors: AstraZeneca Recruiting

• Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen

  Conditions: Carcinoid Syndrome; Carcinoid; Carcinoid Tumor; Carcinoid Tumor of Ileum; Carcinoid Tumor of Cecum; Carcinoid Tumor of Liver; Carcinoid Tumor of Pancreas; Carcinoid Syndrome Diarrhea; Carcinoid Intestine Tumor Interventions: Drug: Paltusotine; Drug: Placebo Sponsors: Crinetics Pharmaceuticals Inc. Recruiting

• Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

  Conditions: Small Cell Lung Carcinoma; Large Cell Neuroendocrine Carcinoma of the Lung; Neuroendocrine Prostate Cancer; Gastroenteropancreatic Neuroendocrine Carcinoma Interventions: Drug: 225Ac-ETN029; Drug: 111In-ETN029 Sponsors: Novartis Pharmaceuticals Recruiting

• Effects of Sleep Hygiene Education and Progressive Relaxation Exercise on Anxiety, Sleep Quality and Glycemic Control in Diabetic Patients

  Conditions: Diabetes Mellitus, Type 2 Interventions: Other: sleep hygiene education and progressive relaxation exercise Sponsors: Gazi University Enrolling by invitation

• Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

  Conditions: Pancreatic Neuroendocrine Tumor (pNET); Extra-Pancreatic Neuroendocrine Tumor (epNET) Interventions: Drug: Zanzalintinib; Drug: Everolimus Sponsors: Exelixis Recruiting

• A Study of 177Lu-DTPA-SC16.56 in People With Neuroendocrine Carcinomas of the Lung and Prostate

  Conditions: Neuroendocrine Tumor of the Lung; Neuroendocrine Carcinoma of Lung; Neuroendocrine Carcinoma; Neuroendocrine Carcinoma of Prostate Interventions: Diagnostic Test: PET/CT; Biological: 177Lu-DTPA-SC16.56 Sponsors: Memorial Sloan Kettering Cancer Center Not yet recruiting

• Resection of the Primary Tumor vs. Systemic Treatment Alone for Patients With Small Intestinal Neuroendocrine Tumors and Unresectable Metastases: a Europe-wide Study

  Conditions: Neuroendocrine (NE) Tumors; Metastasis; Bowel Obstruction Interventions: Other: Histopathological review Sponsors: Insel Gruppe AG, University Hospital Bern Recruiting

• Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

  Conditions: Somatostatin Receptor Positive (SSTR+); Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) Interventions: Radiation: [177Lu]Lu-DOTA-TATE; Drug: Octreotide LAR Sponsors: Novartis Pharmaceuticals Recruiting

• Study of 225Ac-ABD147 to Establish Optimal Dose in Patients With SCLC and LCNEC of the Lung That Previously Received Platinum-based Chemotherapy

  Conditions: Small-Cell Lung Cancer (SCLC); Large Cell Neuroendocrine Carcinoma of the Lung Interventions: Drug: 225Ac-ABD147 Sponsors: Abdera Therapeutics Inc. Recruiting

• Acute Effects of Ultra-processed Versus Unprocessed Foods on Glucocorticoid Secretion in Healthy Individuals

  Conditions: Glucocorticoids; Obesity and Overweight; Food Effect Interventions: Other: Ultra-processed breakfast; Other: Low-processed breakfast Sponsors: Eleonora Seelig Completed

• Window On the Brain

  Conditions: Disorders of Consciousness Interventions: Device: Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention Sponsors: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; IRCCS Istituto delle Scienze Neurologiche di Bologna; S.Anna Rehabilitation Institute; IRCCS Centro Neurolesi Bonino Pulejo Recruiting

• Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma

  Conditions: Vestibular Schwannoma Interventions: Combination Product: AAVAnc80-antiVEGF via Akouos Delivery Device Sponsors: Akouos, Inc.; Eli Lilly and Company Recruiting

• Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

  Conditions: Long Covid; Post-treatment Lyme Disease Syndrome; Chronic Fatigue Syndrome; Myalgic Encephalomyelitis Interventions: Dietary Supplement: Lumbrokinase Sponsors: Icahn School of Medicine at Mount Sinai; Columbia University; PolyBio Research Foundation Recruiting

• Antiviral Clinical Trial for Long Covid-19

  Conditions: Long Covid Interventions: Drug: tenofovir disoproxil/emtricitabine; Drug: Selzentry; Drug: Placebo Sponsors: Icahn School of Medicine at Mount Sinai; Yale University; PolyBio Research Foundation Recruiting

• Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy

  Conditions: Myelodysplastic Syndrome; Acute Myeloid Leukemia Interventions: Radiation: Peptide receptor radionuclide therapy (PRRT); Diagnostic Test: Blood collection Sponsors: University Health Network, Toronto Recruiting

• Defining Response Criteria for PET Scans for People With Neuroendocrine Tumors

  Conditions: Neuroendocrine Tumors Interventions: Diagnostic Test: positron emission tomography (PET) scans Sponsors: Memorial Sloan Kettering Cancer Center; NeuroEndocrine Tumor Research Foundation (NETRF) Active, not recruiting

• Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy

  Conditions: Somatostatin Receptor Positive; Gastrointestinal Neuroendocrine Tumors; Pheochromocytoma; Paragangliomas Interventions: Drug: 68Ga-DOTATATE; Drug: [203Pb]VMT-alpha-NET; Drug: [212Pb]VMT-alpha-NET Sponsors: National Cancer Institute (NCI) Recruiting

• A Study of FZ-AD005 in Patients With Advanced Solid Tumors

  Conditions: Advanced Solid Tumor, SCLC(Small Cell Lung Cancer) or LCNEC (Large Cell Neuroendocrine Carcinoma) Interventions: Drug: FZ-AD005 Sponsors: Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Recruiting

• A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity

  Conditions: Carcinoma, Neuroendocrine; Tumor, Neuroendocrine; Tumors, Neuroendocrine; Neuroendocrine; Carcinoma; Small Cell; Receptors Interventions: Drug: Belinostat; Drug: Cisplatin; Drug: Etoposide Sponsors: National Cancer Institute (NCI) Recruiting

• NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.

  Conditions: Metastatic Neuroendocrine Prostate Cancer Interventions: Drug: [68Ga]Ga-PSMA-11; Drug: [68Ga]GA-DOTA-TATE; Drug: [68Ga]Ga-NeoB; Drug: [177Lu]Lu-PSMA-617; Drug: [177Lu]Lu-DOTA-TATE; Drug: [177Lu]Lu-NeoB; Drug: L-Lysine HCl-L-Arginine HCl, 2.5 %,; Drug: Gonadotropin-releasing hormone (GnRH) analogues; Drug: GnRH antagonists; Drug: Antiemetics & antinauseants; Drug: Metoclopramide Sponsors: Novartis Pharmaceuticals Active, not recruiting

• A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

  Conditions: Basal Ganglia Germinoma; Central Nervous System Germinoma; Diabetes Insipidus; Pineal Region Germinoma; Suprasellar Germinoma; Thalamic Germinoma Interventions: Radiation: 3-Dimensional Conformal Radiation Therapy; Procedure: Biospecimen Collection; Drug: Carboplatin; Drug: Etoposide; Radiation: Intensity-Modulated Radiation Therapy; Procedure: Lumbar Puncture; Procedure: Magnetic Resonance Imaging; Other: Questionnaire Administration; Procedure: Surgical Procedure Sponsors: Children's Oncology Group Recruiting

• Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas

  Conditions: Digestive System Neuroendocrine Neoplasm; Lung Neuroendocrine Neoplasm; Malignant Solid Neoplasm; Pancreatic Neuroendocrine Neoplasm Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Biological: Incomplete Freund''s Adjuvant; Procedure: Magnetic Resonance Imaging; Biological: Sargramostim; Biological: SVN53-67/M57-KLH Peptide Vaccine; Drug: Temozolomide Sponsors: Roswell Park Cancer Institute Recruiting